Take the Toenail Fungus Check-Up to find out!If you have heart disease and abnormal heart rhythms, or people are taking certain medications (e.g., verapamil, atazanavir), discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.For treatment with itraconazole longer than 30 days, your doctor will order lab tests to monitor liver function. Menscer DM. To see the full article, log in or purchase access.INR = International Normalized Ratio; NSAID = nonsteroidal anti-inflammatory drug; HMG-CoA = 3-hydroxy-3-methylglutaryl–coenzyme A reductase inhibitor; SSRI = selective serotonin reuptake inhibitorINR = International Normalized Ratio; NSAID = nonsteroidal anti-inflammatory drug; HMG-CoA = 3-hydroxy-3-methylglutaryl–coenzyme A reductase inhibitor; SSRI = selective serotonin reuptake inhibitor*—Combining an agent that inhibits cytochrome P450 metabolism with a substrate of cytochrome P450 may potentiate the pharmacologic effects of the substrate through inhibition of hepatic metabolism*—Combining an agent that inhibits cytochrome P450 metabolism with a substrate of cytochrome P450 may potentiate the pharmacologic effects of the substrate through inhibition of hepatic metabolismComplete database for drug interactions as well as clinically useful drug information; updated quarterlyHansten and Horn's Drug Interactions Analysis and Management (manual)Easy-to-use index that categorizes a drug interaction by clinical significance, along with a concise reference monograph discussing the interaction; updated quarterlyHandbook of Adverse Drug Interactions (manual); Adverse Drug Interactions Program (software, Internet)Software searches for interactions between two and up to 25 drugsDrug Interactions Analysis and Management (loose-leaf or bound manual); Drug Interaction Facts (loose-leaf or bound manual with software)Information about drug-drug and drug-food interactions in a quick reference format, along with descriptive monographs of drug interactions selected on the basis of their potential to alter patient outcomes; updated quarterlyComplete database for drug interactions as well as clinically useful drug information; updated quarterlyHansten and Horn's Drug Interactions Analysis and Management (manual)Easy-to-use index that categorizes a drug interaction by clinical significance, along with a concise reference monograph discussing the interaction; updated quarterlyHandbook of Adverse Drug Interactions (manual); Adverse Drug Interactions Program (software, Internet)Software searches for interactions between two and up to 25 drugsDrug Interactions Analysis and Management (loose-leaf or bound manual); Drug Interaction Facts (loose-leaf or bound manual with software)Information about drug-drug and drug-food interactions in a quick reference format, along with descriptive monographs of drug interactions selected on the basis of their potential to alter patient outcomes; updated quarterlyAddress correspondence to Paul W. Ament, Pharm.D., Clinical Pharmacy Services, Latrobe Area Hospital, 121 W. 2nd Ave., Latrobe, PA 15650. down the sink or in the toilet) or in household garbage. Tyler DL, Klostermeyer BS. Alternative antimicrobial therapy is recommended for these patients.Some investigators advise that the hypothrombinemic response to warfarin can increase when acetaminophen is taken in a dosage of more than 2 g per day for longer than one week.One case-control study identified acetaminophen as a cause of 30 percent of INR values greater than 6.0 in patients taking warfarin.Because acetaminophen is the most frequently ingested medication in the United States, physicians should counsel warfarin-treated patients about the potential risks of a warfarin-acetaminophen interaction.
All SSRIs except paroxetine (Paxil) have pharmacologically active metabolites.The most common interactions with SSRIs result from an inhibitory effect of the SSRI on the cytochrome P450 2D6 pathway, although variability in this inhibition exists. Basile F, Drugs with a narrow therapeutic range or low therapeutic index are more likely to be the objects for serious drug interactions. A WARNING ABOUT MILK THISTLE AND DRUGS The seeds of the milk thistle plant are commonly used to protect the liver from damage caused by hepatitis viruses as well as alcohol and other substances.
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