HRT, especially oestrogen-progestogen combined treatment, increases the density of mammographic images which may adversely affect the radiological detection of breast cancer.Ovarian cancer is much rarer than breast cancer. For initiation and continuation of treatment of menopausal symptoms, the lowest effective dose for the shortest duration (see also Section 4.4) should be used. The number of extra cases of CAD due to oestrogen-progestogen use is very low in healthy women close to menopause, but will rise with more advanced age.Combined oestrogen-progestogen and oestrogen-only therapy are associated with an up to 1.5-fold increase in risk of ischaemic stroke. Remove one part of the protecting foil. Treatment should not be restarted until the woman is completely mobilised.If VTE develops after initiating therapy, the drug should be discontinued. There is some evidence of increased risk of probable dementia in women who start using continuous combined or oestrogen-only HRT after the age of 65.Contact sensitisation is known to occur with all topical applications. T3 resin uptake is decreased, reflecting the elevated TBG. Theramex HQ UK Ltd , Sloane Square House , 1 Holbien Place , London , SW1W 8NS
deep vein thrombosis or pulmonary embolism. The percentage of women who maintained or gained BMD in the lumbar zone during treatment was 90%.Evorel Conti also had an effect on hip BMD. untreated atypical endometrial hyperplasia)- Previous idiopathic or current venous thrombo-embolism (deep venous thrombosis, pulmonary embolism)- Active or recent past arterial thrombo-embolic disease (eg cerebrovascular accident angina, myocardial infarction)- Acute liver disease, or a history of liver disease as long as liver function tests have failed to return to normal- Known thrombophilic conditions (e.g. This system is protected by a polyester foil release liner, which is affixed to the adhesive matrix and is removed prior to application of the patch to the skin. The second layer is a monolayer adhesive film (matrix) composed of acrylic adhesive and guar gum and contains the hormones. �� endstream
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If pregnancy occurs during use of Evorel Conti, treatment should be withdrawn immediately.Data on a limited number of exposed pregnancies indicate adverse effects of norethisterone on the foetus. The first layer is a flexible, translucent, and nearly colourless backing film. During treatment, periodic check-ups are recommended of a frequency and nature adapted to the individual woman. Based on safety data from these clinical trials, the most commonly reported (≥5% incidence) adverse drug reactions (ADRs) were (with % incidence): application site reaction (11.7%), menstrual disorder (7.1%), headache (8.2%), and breast pain (5.1%).Including the above-mentioned ADRs, the following table displays ADRs that have been reported with the use of Evorel Conti from either clinical trial or post-marketing experiences, and additional ADRs that have been reported with the use of Evorel (estradiol alone) from clinical trial data.
1Diabetes mellitus with or without vascular involvement CholelithiasisMigraine or (severe) headache Systemic lupus erythematosusA history of endometrial hyperplasia (see below) Epilepsy Symptoms of overdose with oral oestrogens are breast tenderness, nausea, vomiting and/or metrorrhagia. The release liner has a S-shaped opening to facilitate its removal prior to use. Investigations, including appropriate imaging tools, e.g mammography, should be carried out in accordance with currently accepted screening practices, modified to the clinical needs of the individual.If any of the following conditions are present, have occurred previously, and/or have been aggravated during pregnancy or previous hormone treatment, the patient should be closely supervised.
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