But I agree, injectable estradiol valerate or cypionate at least 7 mg every 5 days without antiandrogen (with finasteride 0.05-0.1 mg/day in case of male pattern baldness in the past) is a safe and effective MtF HRT regimen. Even in doses as high as 600 mg/day, there were no additional dose-limited side effects.In two large phase III studies, comparing 50 mg Casodex/day with castration, Casodex was found to be inferior in terms of the time of progression and survival. It's a very powerful drug and long lasting of a "half life" so 50 mg might be way over kill.I had a bit of an off an on slight headache for the first few weeks taking it but that went away and now I have zero side effects.That's a first for me with an AA as spiro would make me occasionally pass out from low blood pressure and finasteride would make me feel like I had vertigo and made my lower anatomy go through some weird monthly pain that I just didn't care for.The serum testosterone levels may increase or stay flat as it doesn't really do anything with that. and then I looked, and when exactly did there start being actual discussion there?OP mentions tumblr, that's transmasc territory so maybe the bros would have something to contribute.New comments cannot be posted and votes cannot be castPress J to jump to the feed. 263–263). I am wondering if there are any girls out there that are on Bicalutamide, and how it has affected their feminization. ... so today I started my first dose of Bicalutamide at 25mg for the first week, then up to 50 mg. In Hormone Research in Paediatrics (Vol. Bicalutamide can be considered a more potent AA than spironolactone, but at least at the outset of MtF HRT it is probably better to take a higher dose rather than a lower dose (and a minimum of 50 mg/day). 266–267).Hovinga, I. K., & Stuart, A. V. (2016, January). 1mg of bicalutamide ACTUALLY blocks 10ng/dl of testosterone and dht from binding to the androgen receptor see here: "Although the affinity of bicalutamide for the AR is approximately 30 to 100 times lower than that of DHT (IC50 ≈ 3.8 nM), the main endogenous ligand of the receptor in the prostate gland, sufficiently high relative concentrations of bicalutamide …
Unlike spironolactone, it does appear to present some risk of serious liver disease/injury, but the overall risk appears to be low.Spironolactone is mainly used in the USA where cyproterone acetate (the other main anti-androgen) has never been licensed for any indication. gynaecomastia, hot flushes, impotence, decreased libido and inhibition of spermatogenesis).NSAAs are usually used in combination therapy with either chemical or surgical castration in advanced metastatic prostate cancer.Chemical castration is accomplished with a GnRH agonist, which shuts down testicular function.Estrogen antagonists and other androgens have been used to help reduce the incidence of antiandrogen side effects.A 1.8-Å resolution X-ray crystal structure of the this mutant with R-bicalutamide shows that it binds at the dihydrotestosterone binding site for the wild-type androgen receptor (Advanced prostate cancer treatment requires drugs that have superior binding affinity (more than that for bicalutamide) to the androgen receptor.
 Doses of 200mg daily in non-transgender women being treated for hair loss have been described as …
72, pp. Phase I/II clinical trials of two fluorinated drugs, RD162 and MDV3100 ) (In extensive dose-ranging studies, a series of phase II and phase III studies confirmed the dose of 150 mg/day as appropriate for monotherapy.
497 Drugs such as spironolactone, cyproterone acetate, marijuana, and H 2 receptor antagonists (specifically cimetidine) have AR antagonist activity.
Treatment options can seem overwhelming to people with rheumatoid arthritis (RA) or other rheumatic conditions. While my face looks completely passable, the spiro caused me to lost so much weight that i have no hip growth and barely an AA breast cup/ Any input is greatly appreciated.I am and I absolutely adore it.
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