ciprofloxacin vs cefpodoxime


The microbiological cure rate was 96% (123/128) for ciprofloxacin compared with 81% (104/129) for cefpodoxime (difference of 15%; 95% CI, 8%-23%). Microbiologic cure rate at 5 days was 96% in the ciprofloxacin group and 81% in the cefpodoxime group. title = "Cefpodoxime vs ciprofloxacin for short-course treatment of acute uncomplicated cystitis: A randomized trial", abstract = "Context: Although fluoroquinolones remain the most reliable urinary antimicrobial, resistance rates have increased and effective fluoroquinolone-sparing antimicrobials are needed. Interventions: Patients were given 250 mg of ciprofloxacin orally twice daily for 3 days or 100 mg of cefpodoxime proxetil orally twice daily for 3 days. Main Outcome Measures: Overall clinical cure (defined as not requiring antimicrobial treatment during follow-up) at the 30-day follow-up visit. Among women with follow-up, 99% of the ciprofloxacin group and 98% of the cefpodoxime group reported … These findings, along with concerns about possible adverse ecological effects associated with other broad-spectrum β-lactams, do not support the use of cefpodoxime as a first-line fluoroquinolone-sparing antimicrobial for acute uncomplicated cystitis. These findings, along with concerns about possible adverse ecological effects associated with other broad-spectrum β-lactams, do not support the use of cefpodoxime as a first-line fluoroquinolone-sparing antimicrobial for acute uncomplicated cystitis. The hypothesis that cefpodoxime would be noninferior to ciprofloxacin by a 10% margin (ie, for the difference in the primary outcome for ciprofloxacin minus cefpodoxime, the upper limit of the confidence interval would be <10%) was formulated prior to data collection. and 380 patients on cefixime 4 mg/kg b.i.d. AU - Hooton, Thomas M. AU - Roberts, Pacita L. AU - Stapleton, Ann E. PY - 2012/2/8. Vantin (cefpodoxime) is good for treating many bacterial infections and it works best if you take the full course without stopping.

4 Study subjects were randomized to receive either 250 mg of ciprofloxacin orally twice daily for 3 days or 100 mg of cefpodoxime proxetil orally twice daily … Ciprofloxacin is prescribed for Infection and UTI and is mostly mentioned together with these indications. Look at the microbiologic cure rates–cipro was right on line at 96%, whereas cefpodoxime performed much lower than expected at 81%. Bacterial eradication was 93.4% with cefpodoxime and 82.9% with cefixime. 95.6% in the cefpodoxime group and 90.9% in the ciprofloxacin group. This study demonstrates, yet again, that this is incorrect reasoning.Ryan P. Radecki, MD MS FACEP is a specialist in Emergency Medicine at Christchurch Hospital in New Zealand, former AHRQ Patient Safety and Quality The opinions here expressed represent those solely of the author, and no employers or academic affiliates.…but don’t use either of them first-line. 2005 Feb 23;293(8):949-55. doi: 10.1001/jama.293.8.949.J Antimicrob Chemother. Nitrofurantoin and fosfomycin are recommended as first-line therapy in the most recent guidelines, along with trimethoprim-sulfamethoxazole depending on local resistance. COVID-19 is an emerging, rapidly evolving situation. Trial Registration: clinicaltrials.gov Identifier: NCT00194532AB - Context: Although fluoroquinolones remain the most reliable urinary antimicrobial, resistance rates have increased and effective fluoroquinolone-sparing antimicrobials are needed. These findings, along with concerns about possible adverse ecological effects associated with other broad-spectrum β-lactams, do not support the use of cefpodoxime as a first-line fluoroquinolone-sparing antimicrobial for acute uncomplicated cystitis. 2012;307(13):1394-1404. Trial Registration: clinicaltrials.gov Identifier: NCT00194532UR - http://www.scopus.com/inward/record.url?scp=84856782630&partnerID=8YFLogxKUR - http://www.scopus.com/inward/citedby.url?scp=84856782630&partnerID=8YFLogxKJO - JAMA - Journal of the American Medical AssociationJF - JAMA - Journal of the American Medical Association"We use cookies to help provide and enhance our service and tailor content. 95.6% in the cefpodoxime group and 90.9% in the ciprofloxacin group. Design, Setting, and Patients: Randomized, double-blind trial of 300 women aged 18 to 55 years with acute uncomplicated cystitis comparing ciprofloxacin (n=150) with cefpodoxime (n=150); patients were from a student health center in Seattle, Washington, and a referral center in Miami, Florida. Secondary outcomes were clinical and microbiological cure at the first follow-up visit and vaginal Escherichia coli colonization at each follow-up visit. T2 - A randomized trial. Trial Registration: clinicaltrials.gov Identifier: NCT00194532T1 - Cefpodoxime vs ciprofloxacin for short-course treatment of acute uncomplicated cystitisN2 - Context: Although fluoroquinolones remain the most reliable urinary antimicrobial, resistance rates have increased and effective fluoroquinolone-sparing antimicrobials are needed. The hypothesis that cefpodoxime would be noninferior to ciprofloxacin by a 10% margin (ie, for the difference in the primary outcome for ciprofloxacin minus cefpodoxime, the upper limit of the confidence interval would be <10%) was formulated prior to data collection.

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